Meat Boy and Bandage Girl are in love, but Dr. Fetus, an intelligent fetus in a jar piloting a mechanical suit, is unloved and hates everyone. In a fit of jealousy, Dr. Fetus kidnaps Bandage Girl. Meat Boy chases Dr. Fetus through increasingly dangerous environments to rescue her, facing obstacles and boss creatures along the way, while Dr. Fetus repeatedly escapes with Bandage Girl at the end of each chapter.