3 months have passed since the biological disaster in Raccoon City. Claire Redfield, having survived along with Leon S. Kennedy and Sherry Birkin, travels to France in search of her brother, Chris Redfield. However, what awaits her is not a reunion with her brother, but the Umbrella special forces unit responsible for the incident. They capture Claire and transport her to a mysterious island. Now Claire must make a desperate attempt to escape the remote Rockfort Island, which, due to another biological disaster, has transformed into a living hellscape of survival horror.